Gut health and depression are strongly linked to each other

gut health and depression

There is a strong connection between gut health and depression. You know the gut is considered to be our second brain. Emotion like depression, anxiety or stress is also linked to our gut health as well as our mental health. This connection of our gut health and depression is in a bidirectional pathway.

People with poor gut health easily experience mental issues like depression and anxiety. Depression also causes several problems of gut health like the disruption of the composition of gut bacteria, leaky gut syndrome, and inflammation.

The link between gut health and depression or anxiety:

The sympathetic and parasympathetic branch of the autonomic nervous system mediates the communication between the central nervous system (CNS) and the enteric nervous system (ENS).

A large amount of serotonin induces the receptors responsible for peristalsis and secretion in the gastrointestinal tract and thus improves the communication between the gut and brain.

The communication between the central nervous system (CNS) and enteric nervous system (ENS) is mediated by the vagus nerve, prevertebral ganglia, immune activation, intestinal barrier function, enteroendocrine signaling.

The nerve called vagus nerve transfers messages from the gut to the brain and vice versa. This nerve also sends information from other organs (lungs and heart) to the brain. The gut release hormone and neurotransmitter (dopamine, serotonin) to transfer information from the gut to the brain.


Several microbes release hormones and neurotransmitters to regulate mental health.
List of gut bacteria with their hormone and neurotransmitter [1]

BACILLUS                                         Dopamine, norepinephrine
BIFIDO-BACTERIUM                   Gamma-aminobutyric acid (GABA)
ENTEROCOCCUS                           Serotonin
ESCHERICHIA                                Norepinephrine, serotonin
LACTOBACILLUS                           Acetylcholine, GABA
STREPTOCOCCUS                          Serotonin


Gut health and mental health in a bi-directional pathway:

The gut is connected with the brain in a bidirectional pathway. This pathway is called the gut-brain axis. The vagus nerve transfers the message through this axis between the gut and brain. This nerve is considered to be the longest nerve in the human body which connects the gut directly with the brain.

The gut-brain axis comprises the CNS, the neuroendocrine and neuroimmune system, the autonomic nervous system, the enteric nervous system (ENS) and gut microbiota.
In one way, the central nervous system can indirectly influence gut microbiota by causing changes in gastrointestinal motility, secretion, and/or intestinal permeability, or may directly affect microbiota by stimulating the release of molecules from enterochromaffin cells, neurons, and immune cells.
On the other way, gut microbiota sends messages to the brain via multiple ways such as direct stimulation of receptor-mediated signaling and enterochromaffin-cell signaling.

Mental health problem is strongly connected to a gut health problem such as constipation, gas, bloating and chronic diarrhea.
On the other hand, dysbiosis (imbalance of gut bacteria) and gut inflammation can affect the nervous system and cause several mental health problems such as Parkinson’s disease, autism, anxiety, and depression.

Stress-induced alteration to gut microbiota can cause the possibility of intestinal permeability or leaky gut. A leaky gut can cause diarrhea, increased inflammation, abdominal pain/cramping, allergies, skin problem, gastrointestinal tract obstructions, and various diseases.

Stress can alter the composition of gut bacteria causing an imbalance of gut bacteria or dysbiosis.
Stress can cause a great change in the composition of gut microbiota.
Chronic stress also causes damage to the gut barrier and make it leaky. Therefore, it increases the number of immunomodulatory compounds of bacterial cell walls such as lipopolysaccharide.

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Gut health and anxiety or depression:

Scientists showed that mice with stress and autism have a lower level of Bacteroids fragilis in their gut.
They also showed that depressed people have a decreased amount of good bacteria such as Coprococcus and Dialister in their gut.
On the other hand, mentally healthy people have a sufficient amount of Faecalibacterium and Coprococcus.

When the scientists fed the mice, they recovered their mental health problems. They confirmed that the treatment of mice with B. fragilis cause the mice to become social and mentally sound.
In other research, scientists collected bacteria from depressed people and inoculated it in mice. This causes depression in mice.

The link between gut health and anxiety depends on the balance of gut bacteria


The composition of gut microbiota:

The gut bacteria strongly influence our gut health and depression

  • There are 100 trillion microorganisms in the gut. They weigh approximately 2 kg. Among them, 1000 unique species of bacteria are found in the human gut. Gut microbiota comprises more than 1000 microbial species and more than 7000 strains.
  • 95% of bacteria of our human body live in our digestive tract.
  • The composition of our gut microbiota is unique just like our fingerprints.


Comparison of Brain with gut (second brain):

Gut health and depression are linked to each other due to the production of neurotransmitters.

  • Central nervous system (CNS) contains 85 billion neurons. Enteric nervous system contains 500 million neurons.
  • Researchers identified 100 neurotransmitters in CNS and 40 neurotransmitter in ENS.
  • CNS produces 50% of all dopamine and ENS produces the rest 50% of all dopamine.
  • CNS produces 5% of all serotonin and ENS produces the rest 95% of all serotonin.

Probiotic bacteria help in reducing anxiety and depression:

  • Microorganisms always play an important role in reducing depression and anxiety.
  • Probiotic bacteria such as L. rhamnosus reduce stress. Moreover a combination of Lactobacillus helveticus R0052 and B. longum R0175 help in reducing anxiety and depression.
  • Several studies say that Lactobacillus farciminis can prevent barrier permeability of the gut.

See also: 10 Best Probiotics for Gut Health

Gut bacteria might influence mental health


Reference of Hormone (or neurotransmitter)

1. Journal of Psychiatric Research, ‘Collective unconscious: How gut microbes shape human behavior’, April 2015

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