8 controversies about phage therapy

Phage viruses have attracted a great attention  recently as it is now considered one of the best alternatives to antibiotics.
Phages are the viruses that can replicate in the bacterial host cells, kill pathogenic bacterial cells, and are able to produce new lytic phages to keep pace with the mutation of pathogens. However, the replacement of antibiotics by phages in the treatment of bacterial diseases encounters several controversies because of the following reasons:

Read more8 controversies about phage therapy

10 mechanisms of antibiotic resistance in Bacteria

Antibiotic resistance is now considered to be a great curse to the present world. Researcher suspected that millions of people will die due to the rapid emergence of antibiotic resistance by 2050. There are lots of mechanisms of antibiotic resistance. All the mechanisms of antibiotic resistance can be narrowed into two part; mutation and horizontal gene transfer. In this context, the last mechanism belongs to horizontal gene transfer-mediated resistance and most of the other mechanisms of antibiotic resistance are mutation-mediated.

Read more10 mechanisms of antibiotic resistance in Bacteria

20 Characteristics of Viruses

Viruses are one of the most numerous microorganisms on our earth and infect all types of cells (such as human cells, animal cells, plant cells, bacterial cells and fungal cells etc). So, viruses are interesting microbes to study for what they can tell us about the genetics and biochemistry of cellular mechanisms and about the process to develop a disease. Characteristics of virus may help you find a microorganism as virus.

Read more20 Characteristics of Viruses

Types of exotoxin and list of exotoxins

Exotoxins are proteins produced by both gram-positive bacteria and gram-negative bacteria. There are different types of exotoxin. They are considered to be among most lethal substances as they can easily disseminate in blood for their high solubility. A little amount of exotoxins is sufficient to be a lethal dose. For example, 1mg of botulinum toxins is enough to kill 1 million guinea pigs.

Read moreTypes of exotoxin and list of exotoxins

5 drawbacks of phage therapy

Bacteriophage therapy is now considered to be the best alternative therapeutics to antibiotic treatment. Although phage therapy was started in 1919, the concept of phage therapy died out in the 1940s due to the production of antibiotics in large amount.

Read more5 drawbacks of phage therapy

Ten advantages of phage therapy over antibiotics

Phage therapy is the use of phage viruses (bacteriophage) to kill bacterial pathogens as well as drug-resistant bacteria that cause life-threatening infection in the human body. Phage therapy was started in 1919, a few years after the discovery of phage by Frederick Twort (1915) and Felix d’He’relle (1917). But a decade later, due to the discovery of first antibiotic penicillin and emergence of pharmaceutical antibiotics in large quantities, the concept of phage therapy died out by 1940s in west Europe.

Read moreTen advantages of phage therapy over antibiotics

How bacteria are used to fight against cancer

Cancer is one of the major causes of death in the world. Although a lot of research have been done to combat cancer, treatment of this disease didn’t give full hope to save lives of cancer patients. Conventional chemotherapies used against cancer, have some drawbacks. For example, chemotherapeutic agents that kill cancer cells, have non-specific toxic effect to the normal cells.

Read moreHow bacteria are used to fight against cancer

Ten phages that cause human disease

Bacteriophages are of two types: lytic and lysogenic bacteriophages. Lytic phages are virulent, causing lysis of bacterial cells, allowing lytic phage progeny to be released into the environment. Due to their lytic properties specific to bacteria, they are supposed to be used as alternative therapeutics against multi-drug resistant bacteria. On the other hand, lysogenic phages are the viruses that integrate their whole genome into bacterial chromosome and maintain their DNA replications along with bacterial genome within bacterial cells.

Read moreTen phages that cause human disease

New drug developed for HIV treatment

Since the discovery of HIV virus, scientists have been trying to find a better  HIV treatment. Although few antiretroviral drugs have been developed, they couldn’t give full hope to the patient.

Recently, a new drug “Gammora”  has been developed by Israeli scientists, which can eradicate up to 99% of HIV infected cells. The drug gammora in its first human trial has been succeeded to get this positive result.
Researchers of Zion Medical, an Israeli Biotech Company developed this drug and they proved that the drug can eliminate up to 99% of viral load even within first four week of treatment.

Read moreNew drug developed for HIV treatment

10 phages used onto food to prevent bacterial pathogens

Antibiotic resistance has become a major concern of this world due to misuse and rapid use of antibiotics. This problem causes scientist to find new strategies to combat bacterial pathogens. As many studies have been done for this purpose, phage therapy is mostly discussed topic at present days.

Frederick Twort in 1915 and Fe’lix d’He’relle in 1917 first observed that viruses have antibacterial activities. Since then, phages had been being used against dome bacteria. But due to discovery of antibiotics in 1929 and its rapid emergence in 1940, the concept of phage application died out in west.

Read more10 phages used onto food to prevent bacterial pathogens